help  | about  | cite  | software

Gene : MED1 Homo sapiens

Name  ? mediator complex subunit 1 Cytological Location  17q12
Brief Description  mediator complex subunit 1
description  The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]
  • synonyms:
  • PPARBP,
  • PPARGBP,
  • RB18A,
  • DRIP230,
  • L40366,
  • MED1,
  • OTTHUMG00000133216,
  • CRSP200,
  • PBP,
  • PPAR binding protein,
  • CRSP1,
  • RB18A,
  • TRAP220,
  • TRAP220,
  • CRSP1,
  • TRIP2,
  • PPARGBP,
  • CRSP200,
  • PPARBP,
  • HGNC:9234,
  • uc002hrv.5,
  • PBP,
  • TRIP2,
  • NM_004774,
  • DRIP205,
  • DRIP230
  • identifiers:
  • 5469,
  • ENSG00000125686,
  • MED1

Genome feature

Region: gene ? Length: 46997  
Location: 17:39404285-39451281 reverse strand Cyto location: 17q12


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

44 SN Ps

5 Cross References

17 Data Sets

5 Homologues

10 Located Features

90 Rna Seq Results