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Gene : PRG2 Homo sapiens

Name  ? proteoglycan 2, pro eosinophil major basic protein Cytological Location  11q12.1
Brief Description  proteoglycan 2, pro eosinophil major basic protein
description  The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
  • synonyms:
  • NM_002728,
  • BC005929,
  • proMBP,
  • eosinophil major basic protein,
  • MBP,
  • proMBP,
  • MBP,
  • PRG2,
  • MBP1,
  • HGNC:9362,
  • OTTHUMG00000167027,
  • proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein),
  • uc001nkc.4,
  • BMPG,
  • BMPG
  • identifiers:
  • 5553,
  • ENSG00000186652,
  • PRG2

Genome feature

Region: gene ? Length: 3871  
Location: 11:57386787-57390657 reverse strand Cyto location: 11q12.1

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2011 SN Ps

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90 Rna Seq Results