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Gene : MAPK10 Homo sapiens

Name  ? mitogen-activated protein kinase 10 Cytological Location  4q21.3
Brief Description  mitogen-activated protein kinase 10
description  The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
  • synonyms:
  • p54bSAPK,
  • MAPK10,
  • PRKM10,
  • SAPK1b,
  • JNK3A,
  • uc003hpr.4,
  • HGNC:6872,
  • JNK3,
  • p54bSAPK,
  • OTTHUMG00000130604,
  • U07620,
  • p493F12,
  • p493F12,
  • PRKM10,
  • JNK3,
  • NM_001318067
  • identifiers:
  • 5602,
  • ENSG00000109339,
  • MAPK10

Genome feature

Region: gene ? Length: 582330  
Location: 4:86012296-86594625 reverse strand Cyto location: 4q21.3

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55 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Orthologues


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



55 Pathways

2011 SN Ps

5 Cross References

18 Data Sets

27 Homologues

0 Located Features

90 Rna Seq Results