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Gene : PSMC4 Homo sapiens

Name  ? proteasome 26S subunit, ATPase 4 Cytological Location  19q13.2
Brief Description  proteasome 26S subunit, ATPase 4
description  The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
  • synonyms:
  • Tat-binding protein 7,
  • proteasome (prosome, macropain) 26S subunit, ATPase, 4,
  • TBP7,
  • NM_006503,
  • S6,
  • S6,
  • MIP224,
  • RPT3,
  • TBP-7,
  • uc002omq.5,
  • U27515,
  • MB67 interacting protein,
  • MGC8570,
  • MIP224,
  • protease 26S subunit 6,
  • TBP-7,
  • HGNC:9551,
  • PSMC4,
  • MGC23214,
  • MGC13687,
  • OTTHUMG00000182577,
  • TBP7
  • identifiers:
  • 5704,
  • ENSG00000013275,
  • PSMC4

Genome feature

Region: gene ? Length: 10760  
Location: 19:39971005-39981764 Cyto location: 19q13.2

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147 Pathways

Gene --> GO terms.

Mouse Gene --> Allele [Phenotype]


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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



147 Pathways

291 SN Ps

5 Cross References

16 Data Sets

12 Homologues

0 Located Features

90 Rna Seq Results