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Gene : PSMD2 Homo sapiens

Name  ? proteasome 26S subunit, non-ATPase 2 Cytological Location  3q27.1
Brief Description  proteasome 26S subunit, non-ATPase 2
description  The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
  • synonyms:
  • MGC14274,
  • AK095245,
  • S2,
  • Rpn1,
  • RPN1,
  • PSMD2,
  • HGNC:9559,
  • P97,
  • S2,
  • P97,
  • TRAP2,
  • OTTHUMG00000156796,
  • NM_002808,
  • uc003fnn.3,
  • TRAP2,
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
  • identifiers:
  • 5708,
  • ENSG00000175166,
  • PSMD2

Genome feature

Region: gene ? Length: 9957  
Location: 3:184299098-184309054 Cyto location: 3q27.1


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148 Pathways

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148 Pathways

491 SN Ps

5 Cross References

17 Data Sets

7 Homologues

0 Located Features

90 Rna Seq Results