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Gene : ADGRB1 Homo sapiens

Name  ? adhesion G protein-coupled receptor B1 Cytological Location  8q24.3
Brief Description  adhesion G protein-coupled receptor B1
description  Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
  • synonyms:
  • BAI1,
  • ADGRB1,
  • OTTHUMG00000164732,
  • NM_001702,
  • brain-specific angiogenesis inhibitor 1,
  • HGNC:943,
  • GDAIF,
  • BAI1,
  • AB005297
  • identifiers:
  • 575,
  • ENSG00000181790,
  • ADGRB1

Genome feature

Region: gene ? Length: 95307  
Location: 8:142449703-142545009 Cyto location: 8q24.3


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1 Pathways

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

1 Pathways

701 SN Ps

5 Cross References

16 Data Sets

25 Homologues

0 Located Features

90 Rna Seq Results