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Gene : MARCH4 Homo sapiens

Name  ? membrane associated ring-CH-type finger 4 Cytological Location  2q35
Brief Description  membrane associated ring-CH-type finger 4
description  MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
  • synonyms:
  • membrane-associated ring finger (C3HC4) 4,
  • MARCH-IV,
  • MARCH-IV,
  • AB037820,
  • HGNC:29269,
  • uc002vgb.4,
  • MARCH4,
  • NM_020814,
  • RNF174,
  • KIAA1399,
  • OTTHUMG00000154824,
  • membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase,
  • RNF174
  • identifiers:
  • 57574,
  • ENSG00000144583,
  • MARCH4

Genome feature

Region: gene ? Length: 114166  
Location: 2:216257862-216372027 reverse strand Cyto location: 2q35


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Disease

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0 Pathways

92 SN Ps

5 Cross References

15 Data Sets

6 Homologues

0 Located Features

90 Rna Seq Results