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Gene : SELENOK Homo sapiens

Name  ? selenoprotein K Cytological Location  3p21.1
Brief Description  selenoprotein K
description  The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Pseudogenes of this locus have been identified on chromosomes 6 and 19.[provided by RefSeq, Aug 2017]
  • synonyms:
  • SELK,
  • SELENOK,
  • NM_021237,
  • HSPC030,
  • HSPC297,
  • SELK,
  • HGNC:30394,
  • OTTHUMG00000158656
  • identifiers:
  • 58515,
  • ENSG00000113811,
  • SELENOK

Genome feature

Region: gene ? Length: 7040  
Location: 3:53884976-53892015 reverse strand Cyto location: 3p21.1


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0 Pathways

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5 Cross References

13 Data Sets

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0 Located Features

90 Rna Seq Results