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Gene : AKTIP Homo sapiens

Name  ? AKT interacting protein Cytological Location  16q12.2
Brief Description  AKT interacting protein
description  The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
  • synonyms:
  • fused toes (mouse) homolog,
  • fused toes homolog (mouse),
  • FTS,
  • AKTIP,
  • NM_022476,
  • AK023320,
  • FT1,
  • OTTHUMG00000133199,
  • FTS,
  • FLJ13258,
  • uc002ehl.4,
  • HGNC:16710
  • identifiers:
  • 64400,
  • ENSG00000166971,
  • AKTIP

Genome feature

Region: gene ? Length: 13372  
Location: 16:53491040-53504411 reverse strand Cyto location: 16q12.2


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Function

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Gene --> Orthologues

Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

0 Pathways

2011 SN Ps

5 Cross References

15 Data Sets

0 Homologues

0 Located Features

90 Rna Seq Results