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Gene : SHC1 Homo sapiens

Name  ? SHC adaptor protein 1 Cytological Location  1q21.3
Brief Description  SHC adaptor protein 1
description  This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
  • synonyms:
  • SHC1,
  • uc001ffx.4,
  • ShcA,
  • SHC (Src homology 2 domain-containing) transforming protein 1,
  • OTTHUMG00000037295,
  • U73377,
  • SHCA,
  • SHC,
  • HGNC:10840,
  • p66,
  • NM_183001,
  • SHC
  • identifiers:
  • 6464,
  • ENSG00000160691,
  • SHC1

Genome feature

Region: gene ? Length: 12195  
Location: 1:154962298-154974492 reverse strand Cyto location: 1q21.3

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90 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene Ontology

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90 Pathways

58 SN Ps

5 Cross References

17 Data Sets

9 Homologues

0 Located Features

90 Rna Seq Results