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Gene : TEK Homo sapiens

Name  ? TEK receptor tyrosine kinase Cytological Location  9p21.2
Brief Description  TEK receptor tyrosine kinase
description  This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
  • synonyms:
  • VMCM1,
  • uc003zqi.5,
  • TEK,
  • TEK tyrosine kinase, endothelial,
  • TIE-2,
  • L06139,
  • VMCM,
  • CD202B,
  • VMCM,
  • TIE2,
  • TIE-2,
  • angiopoietin-1 receptor,
  • NM_000459,
  • venous malformations, multiple cutaneous and mucosal,
  • GLC3E,
  • TIE2,
  • OTTHUMG00000019712,
  • HGNC:11724,
  • VMCM1,
  • CD202b
  • identifiers:
  • 7010,
  • ENSG00000120156,
  • TEK

Genome feature

Region: gene ? Length: 121038  
Location: 9:27109141-27230178 Cyto location: 9p21.2


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Disease

3 Diseases

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407 SN Ps

5 Cross References

20 Data Sets

56 Homologues

0 Located Features

90 Rna Seq Results