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Gene : WRN Homo sapiens

Name  ? WRN RecQ like helicase Cytological Location  8p12
Brief Description  Werner syndrome RecQ like helicase
description  This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
  • synonyms:
  • RECQ3,
  • Werner syndrome,
  • RECQ3,
  • Werner syndrome RecQ like helicase,
  • WRN,
  • HGNC:12791,
  • uc003xio.5,
  • NM_000553,
  • RECQL2,
  • OTTHUMG00000163894,
  • RECQL3,
  • RECQL2
  • identifiers:
  • 7486,
  • ENSG00000165392,
  • WRN

Genome feature

Region: gene ? Length: 142610  
Location: 8:31033262-31175871 Cyto location: 8p12


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Proteins

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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Homology

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Expression

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2011 SN Ps

5 Cross References

18 Data Sets

8 Homologues

0 Located Features

90 Rna Seq Results