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Gene : CASP4 Homo sapiens

Name  ? caspase 4 Cytological Location  11q22.3
Brief Description  caspase 4
description  This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
  • synonyms:
  • U25804,
  • ICEREL-II,
  • ICE(rel)II,
  • OTTHUMG00000166078,
  • Mih1/TX,
  • Mih1,
  • caspase 4, apoptosis-related cysteine peptidase,
  • caspase 4, apoptosis-related cysteine protease,
  • CASP4,
  • HGNC:1505,
  • TX,
  • ICH-2,
  • NM_001225,
  • uc001pid.2,
  • TX,
  • ICE(rel)II,
  • ICH-2
  • identifiers:
  • 837,
  • ENSG00000196954,
  • CASP4

Genome feature

Region: gene ? Length: 25733  
Location: 11:104942866-104968598 reverse strand Cyto location: 11q22.3


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Disease

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Expression

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Other

283 SN Ps

5 Cross References

16 Data Sets

19 Homologues

0 Located Features

90 Rna Seq Results