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Gene : SORBS2 Homo sapiens

Name  ? sorbin and SH3 domain containing 2 Cytological Location  4q35.1
Brief Description  sorbin and SH3 domain containing 2
description  Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • synonyms:
  • OTTHUMG00000157215,
  • KIAA0777,
  • SORBS2,
  • ARGBP2,
  • ARGBP2,
  • uc003iyi.5,
  • Arg/Abl interacting protein,
  • NM_003603,
  • HGNC:24098,
  • PRO0618
  • identifiers:
  • 8470,
  • ENSG00000154556,
  • SORBS2

Genome feature

Region: gene ? Length: 371273  
Location: 4:185585444-185956716 reverse strand Cyto location: 4q35.1


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0 Pathways

274 SN Ps

5 Cross References

17 Data Sets

22 Homologues

0 Located Features

90 Rna Seq Results