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Gene : API5 Homo sapiens

Name  ? apoptosis inhibitor 5 Cytological Location  11p12
Brief Description  apoptosis inhibitor 5
description  This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
  • synonyms:
  • migration-inducing protein MIG8,
  • AAC11,
  • NM_006595,
  • U83857,
  • API5-like 1,
  • API5L1,
  • API5,
  • AAC-11,
  • fibroblast growth factor 2-interacting factor 2,
  • AAC-11,
  • AAC11,
  • uc001mxf.3,
  • HGNC:594,
  • OTTHUMG00000166395
  • identifiers:
  • 8539,
  • ENSG00000166181,
  • API5

Genome feature

Region: gene ? Length: 32576  
Location: 11:43311955-43344530 Cyto location: 11p12


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Function

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Gene --> Orthologues

Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

0 Pathways

103 SN Ps

5 Cross References

15 Data Sets

4 Homologues

0 Located Features

90 Rna Seq Results