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Gene : AKR1C3 Homo sapiens

Name  ? aldo-keto reductase family 1 member C3 Cytological Location  10p15.1
Brief Description  aldo-keto reductase family 1 member C3
description  This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
  • synonyms:
  • hydroxysteroid (17-beta) dehydrogenase 5,
  • HA1753,
  • HSD17B5,
  • HAKRe,
  • HSD17B5,
  • KIAA0119,
  • NM_003739,
  • PGFS,
  • HGNC:386,
  • prostaglandin F synthase,
  • hluPGFS,
  • HAKRB,
  • aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II),
  • uc001ihu.4,
  • DDX,
  • L43839,
  • DD3,
  • AKR1C3,
  • 3-alpha hydroxysteroid dehydrogenase, type II,
  • HAKRB,
  • PGFS,
  • OTTHUMG00000017585,
  • dihydrodiol dehydrogenase X,
  • DDX
  • identifiers:
  • 8644,
  • ENSG00000196139,
  • AKR1C3

Genome feature

Region: gene ? Length: 58921  
Location: 10:5048766-5107686 Cyto location: 10p15.1


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2011 SN Ps

5 Cross References

18 Data Sets

35 Homologues

0 Located Features

90 Rna Seq Results