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Gene : ACVR2B Homo sapiens

Name  ? activin A receptor type 2B Cytological Location  3p22.2
Brief Description  activin A receptor type 2B
description  Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
  • synonyms:
  • HGNC:174,
  • ActR-IIB,
  • HTX4,
  • activin A receptor, type IIB,
  • ActR-IIB,
  • ACVR2B,
  • OTTHUMG00000131291,
  • uc003cif.4,
  • ACTRIIB,
  • X77533,
  • NM_001106
  • identifiers:
  • 93,
  • ENSG00000114739,
  • ACVR2B

Genome feature

Region: gene ? Length: 38844  
Location: 3:38454299-38493142 Cyto location: 3p22.2


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Disease

1 Diseases

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217 SN Ps

5 Cross References

19 Data Sets

15 Homologues

0 Located Features

90 Rna Seq Results