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Gene : SCARB2 Homo sapiens

Name  ? scavenger receptor class B member 2 Cytological Location  4q21.1
Brief Description  scavenger receptor class B member 2
description  The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
  • synonyms:
  • lysosome membrane protein 2,
  • EPM4,
  • CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II),
  • CD36L2,
  • SR-BII,
  • HGNC:1665,
  • SR-BII,
  • uc003hju.3,
  • D12676,
  • HLGP85,
  • lysosomal integral membrane protein II,
  • LGP85,
  • AMRF,
  • LIMP-2,
  • NM_005506,
  • CD36L2,
  • SCARB2,
  • HLGP85,
  • LIMP-2,
  • OTTHUMG00000130099
  • identifiers:
  • 950,
  • ENSG00000138760,
  • SCARB2

Genome feature

Region: gene ? Length: 55163  
Location: 4:76158737-76213899 reverse strand Cyto location: 4q21.1

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1 Diseases

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2011 SN Ps

5 Cross References

20 Data Sets

27 Homologues

0 Located Features

90 Rna Seq Results