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Gene : ADAMTS4 Homo sapiens

Name  ? ADAM metallopeptidase with thrombospondin type 1 motif 4 Cytological Location  1q23.3
Brief Description  ADAM metallopeptidase with thrombospondin type 1 motif 4
description  This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
  • synonyms:
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4,
  • uc001fyt.5,
  • AB014588,
  • NM_005099,
  • ADAMTS-2,
  • ADMP-1,
  • ADMP-1,
  • ADAMTS4,
  • ADAMTS-2,
  • OTTHUMG00000034349,
  • ADAMTS-4,
  • KIAA0688,
  • HGNC:220
  • identifiers:
  • 9507,
  • ENSG00000158859,
  • ADAMTS4

Genome feature

Region: gene ? Length: 12611  
Location: 1:161189729-161202339 reverse strand Cyto location: 1q23.3


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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

101 SN Ps

5 Cross References

15 Data Sets

34 Homologues

0 Located Features

90 Rna Seq Results