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Gene : GDF15 Homo sapiens

Name  ? growth differentiation factor 15 Cytological Location  19p13.11
Brief Description  growth differentiation factor 15
description  This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016]
  • synonyms:
  • PTGFB,
  • GDF15,
  • PTGFB,
  • PLAB,
  • PLAB,
  • macrophage inhibitory cytokine-1,
  • NAG-1,
  • NM_004864,
  • non-steroidal anti-inflammatory drug-activated gene-1,
  • MIC-1,
  • OTTHUMG00000183360,
  • PDF,
  • PDF,
  • BC008962,
  • MIC1,
  • MIC-1,
  • HGNC:30142,
  • prostate differentiation factor,
  • MIC1,
  • uc002niv.2,
  • NAG-1,
  • GDF-15
  • identifiers:
  • 9518,
  • ENSG00000130513,
  • GDF15

Genome feature

Region: gene ? Length: 7008  
Location: 19:18382170-18389177 Cyto location: 19p13.11


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0 Pathways

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Mouse Gene --> Allele [Phenotype]

Homology

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

0 Pathways

16 SN Ps

5 Cross References

16 Data Sets

39 Homologues

0 Located Features

90 Rna Seq Results