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Gene : TP53I3 Homo sapiens

Name  ? tumor protein p53 inducible protein 3 Cytological Location  2p23.3
Brief Description  tumor protein p53 inducible protein 3
description  The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
  • synonyms:
  • OTTHUMG00000090817,
  • TP53I3,
  • uc002rey.2,
  • NM_004881,
  • HGNC:19373,
  • PIG3,
  • PIG3,
  • AF010309
  • identifiers:
  • 9540,
  • ENSG00000115129,
  • TP53I3

Genome feature

Region: gene ? Length: 8340  
Location: 2:24077428-24085767 reverse strand Cyto location: 2p23.3


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2011 SN Ps

5 Cross References

16 Data Sets

1 Homologues

0 Located Features

90 Rna Seq Results