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Gene : WT1 Homo sapiens

Name  ? WT1 transcription factor Cytological Location  11p13
Brief Description  Wilms tumor 1
description  This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
  • synonyms:
  • AWT1,
  • WAGR,
  • WT33,
  • AWT1,
  • WAGR,
  • WIT-2,
  • NM_000378,
  • WT1,
  • NPHS4,
  • NPHS4,
  • GUD,
  • Wilms tumor 1,
  • WIT-2,
  • HGNC:12796,
  • OTTHUMG00000039556,
  • GUD,
  • uc001mtn.4
  • identifiers:
  • 7490,
  • ENSG00000184937,
  • WT1

Genome feature

Region: gene ? Length: 47765  
Location: 11:32387775-32435539 reverse strand Cyto location: 11p13


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Function

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> GO terms.

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

8 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

0 Pathways

11 SN Ps

5 Cross References

19 Data Sets

44 Homologues

0 Located Features

90 Rna Seq Results