help  | about  | cite  | software

Gene : APLP2 Homo sapiens

Name  ? amyloid beta precursor like protein 2 Cytological Location  11q24.3
Brief Description  amyloid beta precursor like protein 2
description  This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
  • synonyms:
  • uc010sby.3,
  • HGNC:598,
  • APPH,
  • APLP2,
  • L19597,
  • APPL2,
  • OTTHUMG00000165767,
  • APPH,
  • CDEBP,
  • APPL2,
  • amyloid beta (A4) precursor-like protein 2,
  • NM_001642,
  • APLP-2
  • identifiers:
  • 334,
  • ENSG00000084234,
  • APLP2

Genome feature

Region: gene ? Length: 74991  
Location: 11:130069821-130144811 Cyto location: 11q24.3


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

310 SN Ps

5 Cross References

16 Data Sets

7 Homologues

0 Located Features

90 Rna Seq Results