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Gene : PIM1 Homo sapiens

Name  ? Pim-1 proto-oncogene, serine/threonine kinase Cytological Location  6p21.2
Brief Description  Pim-1 proto-oncogene, serine/threonine kinase
description  The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]
  • synonyms:
  • PIM,
  • NM_001243186,
  • uc003onk.4,
  • HGNC:8986,
  • pim-1 oncogene,
  • OTTHUMG00000016426,
  • PIM,
  • PIM1
  • identifiers:
  • 5292,
  • ENSG00000137193,
  • PIM1

Genome feature

Region: gene ? Length: 5283  
Location: 6:37170146-37175428 Cyto location: 6p21.2


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

2 SN Ps

5 Cross References

17 Data Sets

6 Homologues

0 Located Features

90 Rna Seq Results