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Gene : HM13 Homo sapiens

Name  ? histocompatibility minor 13 Cytological Location  20q11.21
Brief Description  histocompatibility minor 13
description  The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • PSENL3,
  • PSENL3,
  • SPPL1,
  • PSL3,
  • uc002wwc.5,
  • IMPAS-1,
  • IMPAS,
  • IMP1,
  • HM13,
  • dJ324O17.1,
  • H13,
  • HGNC:16435,
  • signal peptide peptidase like 1,
  • SPPL1,
  • SPP,
  • presenilin-like protein 3,
  • NM_178580,
  • AL110115,
  • OTTHUMG00000032175,
  • intramembrane protease,
  • SPP,
  • MSTP086,
  • signal peptide peptidase beta,
  • IMP1,
  • PSL3,
  • IMPAS,
  • H13
  • identifiers:
  • 81502,
  • ENSG00000101294,
  • HM13

Genome feature

Region: gene ? Length: 55158  
Location: 20:31514410-31569567 Cyto location: 20q11.21


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Proteins

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SNPs

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Disease

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Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Mouse Gene --> Allele [Phenotype]

Homology

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Expression

Gene(s) --> Significant SNPs (GTex data)

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0 Pathways

2011 SN Ps

5 Cross References

15 Data Sets

10 Homologues

0 Located Features

90 Rna Seq Results