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Gene : INCENP Homo sapiens

Name  ? inner centromere protein Cytological Location  11q12.3
Brief Description  inner centromere protein
description  In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
  • synonyms:
  • FLJ31633,
  • NM_020238,
  • uc001nsx.2,
  • inner centromere protein antigens 135/155kDa,
  • OTTHUMG00000167470,
  • inner centromere protein antigens (135kD, 155kD),
  • INCENP,
  • AF282265,
  • HGNC:6058
  • identifiers:
  • 3619,
  • ENSG00000149503,
  • INCENP

Genome feature

Region: gene ? Length: 31502  
Location: 11:62123973-62155474 Cyto location: 11q12.3


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2011 SN Ps

5 Cross References

17 Data Sets

5 Homologues

0 Located Features

90 Rna Seq Results