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Pathway : Melanoma

Identifier  05218 Description  Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations  Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes The only known environmental risk factor is exposure to ultraviolet UV light and in people with fair skin the risk is greatly increased Melanoma pathogenesis is also driven by genetic factors Oncogenic NRAS mutations activate both effector pathways Raf-MEK-ERK and PI3K-Akt The Raf-MEK-ERK pathway may also be activated via mutations in the BRAF gene The PI3K-Akt pathway may be activated through loss or mutation of the inhibitory tumor suppressor gene PTEN These mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression Melanoma development has been shown to be strongly associated with inactivation of the p16INK4a/cyclin dependent kinases 4 and 6/retinoblastoma protein p16INK4a/CDK4,6/pRb and p14ARF/human double minute 2/p53 p14ARF/HMD2/p53 tumor suppressor pathways MITF and TP53 are implicated in further melanoma progression

1 Data Sets

142 Genes

0 Proteins