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Pathway : Acute myeloid leukemia

Identifier  05221 Description  Acute myeloid leukemia AML is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation program AML accounts for approximately 80% of all adult leukemias and remains the most common cause of leukemia death Two major types of genetic events have been described that are crucial for leukemic transformation A proposed necessary first event is disordered cell growth and upregulation of cell survival genes The most common of these activating events were observed in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sporadically in other RTKs Alterations in myeloid transcription factors governing hematopoietic differentiation provide second necessary event for leukemogenesis Transcription factor fusion proteins such as AML-ETO, PML-RARalpha or PLZF-RARalpha block myeloid cell differentiation by repressing target genes In other cases,  the transcription factors themselves are mutated

1 Data Sets

114 Genes

0 Proteins