help  | about  | cite  | software

Pathway : Prostate cancer

Identifier  05215 Description  Prostate cancer constitutes a major health problem in Western countries It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses GSTP1, growth-factor-signaling pathways NKX31, PTEN, and p27, and androgens AR as critical determinants of the phenotype of prostate-cancer cells Glutathione S-transferases GSTP1 are detoxifying enzymes Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by carcinogens NKX31, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate Inadequate levels of PTEN and NKX31 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis Androgen receptor AR is a transcription factor that is normally activated by its androgen ligand During androgen withdrawal therapy, the AR signal transduction pathway also could be activated by amplification of the AR gene, by AR gene mutations, or by altered activity of AR coactivators Through these mechanisms, tumor cells lead to the emergence of androgen-independent prostate cancer

1 Data Sets

178 Genes

0 Proteins