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Pathway : GnRH signaling pathway

Identifier  04912 Description  Gonadotropin-releasing hormone GnRH secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol DAG and inositol 1,4,5-trisphosphate IP3 DAG activates the intracellular protein kinase C PKC pathway and IP3 stimulates release of intracellular calcium In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion Signaling downstream of protein kinase C PKC leads to transactivation of the epidermal growth factor EGF receptor and activation of mitogen-activated protein kinases MAPKs, including extracellular-signal-regulated kinase ERK, Jun N-terminal kinase JNK and p38 MAPK Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes

1 Data Sets

200 Genes

0 Proteins