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Pathway : GlycosylphosphatidylinositolGPI-anchor biosynthesis

Identifier  00563 Description  Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glycosylphosphatidylinositol GPI anchor Hundreds of GPI-anchored proteins have been identified in many eukaryotes ranging from protozoa and fungi to mammals All protein-linked GPI anchors share a common core structure, characterized by the substructure Man a1-4 GlcN a1-6 myo-inositol-1P-lipid Biosynthesis of GPI anchors proceeds in three stages: i preassembly of a GPI precursor in the ER membrane, ii attachment of the GPI to the C-terminus of a newly synthesized protein in the lumen of the ER, and iii lipid remodeling and/or carbohydrate side-chain modifications in the ER and the Golgi Defects of GPI anchor biosynthesis gene result in a genetic disorder, paroxysmal nocturnal hemoglobinuria

1 Data Sets

50 Genes

0 Proteins