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Pathway : Mucin type O-Glycan biosynthesis

Identifier  00512 Description  O-glycans are a class of glycans that modify serine or threonine residues of proteins Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine GalNAc to serine or threonine The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additional four, cores 5 though 8 Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine

1 Data Sets

58 Genes

0 Proteins