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Gene : NDUFS1 Homo sapiens

Name  ? NADH:ubiquinone oxidoreductase core subunit S1 Cytological Location  2q33.3
Brief Description  NADH:ubiquinone oxidoreductase core subunit S1
description  The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
  • synonyms:
  • PRO1304,
  • OTTHUMG00000132892,
  • MC1DN5,
  • NM_005006,
  • NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase),
  • CI-75k,
  • CI-75Kd,
  • complex I 75kDa subunit,
  • HGNC:7707,
  • CI-75k,
  • uc002vbe.4,
  • NADH dehydrogenase (ubiquinone) Fe-S protein 1 (75kD) (NADH-coenzyme Q reductase),
  • NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,
  • NDUFS1
  • identifiers:
  • 4719,
  • ENSG00000023228,
  • NDUFS1

Genome feature

Region: gene ? Length: 44628  
Location: 2:206114817-206159444 reverse strand Cyto location: 2q33.3

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1 Diseases

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3756 SN Ps

5 Cross References

18 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results