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Gene : TIMP2 Homo sapiens

Name  ? TIMP metallopeptidase inhibitor 2 Cytological Location  17q25.3
Brief Description  TIMP metallopeptidase inhibitor 2
description  This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
  • synonyms:
  • DDC8,
  • HGNC:11821,
  • uc002jwf.4,
  • OTTHUMG00000154517,
  • CSC-21K,
  • NM_003255,
  • CSC-21K,
  • TIMP2,
  • tissue inhibitor of metalloproteinase 2
  • identifiers:
  • 7077,
  • ENSG00000035862,
  • TIMP2

Genome feature

Region: gene ? Length: 72411  
Location: 17:78852977-78925387 reverse strand Cyto location: 17q25.3

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Gene -> HPO annotation (Human Phenotype Ontology)

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



189 SN Ps

5 Cross References

16 Data Sets

10 Homologues

0 Located Features

97 Rna Seq Results