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Gene : F7 Homo sapiens

Name  ? coagulation factor VII Cytological Location  13q34
Brief Description  coagulation factor VII
Description  This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]
  • synonyms:
  • NM_000131,
  • factor VII,
  • HGNC:3544,
  • coagulation factor VII (serum prothrombin conversion accelerator),
  • F7,
  • FVII coagulation protein,
  • uc001vsv.5,
  • OTTHUMG00000017373,
  • eptacog alfa,
  • SPCA
  • identifiers:
  • 2155,
  • ENSG00000057593,
  • F7

Genome feature

Region: gene ? Length: 14913  
Location: 13:113105773-113120685 Cyto location: 13q34


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Disease

2 Diseases

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3756 SN Ps

5 Cross References

19 Data Sets

14 Homologues

0 Located Features

97 Rna Seq Results