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Gene : TNK2 Homo sapiens

Name  ? tyrosine kinase non receptor 2 Cytological Location  3q29
Brief Description  tyrosine kinase non receptor 2
description  This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
  • synonyms:
  • ACK1,
  • p21cdc42Hs,
  • OTTHUMG00000155737,
  • ACK-1,
  • activated Cdc42-associated kinase 1,
  • HGNC:19297,
  • TNK2,
  • ACK,
  • NM_005781,
  • tyrosine kinase, non-receptor, 2,
  • ACK1,
  • uc003fvu.2,
  • p21cdc42Hs,
  • L13738,
  • ACK
  • identifiers:
  • 10188,
  • ENSG00000061938,
  • TNK2

Genome feature

Region: gene ? Length: 45646  
Location: 3:195863364-195909009 reverse strand Cyto location: 3q29

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Mouse Gene --> Allele [Phenotype]


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0 Pathways

3756 SN Ps

5 Cross References

17 Data Sets

36 Homologues

0 Located Features

97 Rna Seq Results