help  | about  | cite  | software

Gene : PDE4A Homo sapiens

Name  ? phosphodiesterase 4A Cytological Location  19p13.2
Brief Description  phosphodiesterase 4A
Description  The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
  • synonyms:
  • phosphodiesterase 4A, cAMP-specific,
  • DPDE2,
  • phosphodiesterase E2 dunce homolog (Drosophila),
  • PDE4,
  • OTTHUMG00000180411,
  • uc002mom.3,
  • PDE4A,
  • DPDE2,
  • HGNC:8780,
  • PDE46,
  • phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E2),
  • NM_001111307
  • identifiers:
  • 5141,
  • ENSG00000065989,
  • PDE4A

Genome feature

Region: gene ? Length: 52859  
Location: 19:10416773-10469631 Cyto location: 19p13.2

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer

Gene --> Orthologues


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



295 SN Ps

5 Cross References

17 Data Sets

25 Homologues

0 Located Features

97 Rna Seq Results