help  | about  | cite  | software

Gene : LMAN1 Homo sapiens

Name  ? lectin, mannose binding 1 Cytological Location  18q21.32
Brief Description  lectin, mannose binding 1
description  The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015]
  • synonyms:
  • gp58,
  • MCFD1,
  • FMFD1,
  • HGNC:6631,
  • LMAN1,
  • MCFD1,
  • X71661,
  • F5F8D,
  • coagulation factor V-factor VIII combined deficiency,
  • gp58,
  • ERGIC53,
  • ERGIC-53,
  • F5F8D,
  • ERGIC-53,
  • lectin, mannose-binding, 1,
  • MR60,
  • endoplasmic reticulum-golgi intermediate compartment protein 53,
  • MR60,
  • FMFD1,
  • uc002lhz.4,
  • ERGIC53,
  • OTTHUMG00000132758,
  • NM_005570
  • identifiers:
  • 3998,
  • ENSG00000074695,
  • LMAN1

Genome feature

Region: gene ? Length: 31443  
Location: 18:59327823-59359265 reverse strand Cyto location: 18q21.32

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer

Gene --> Orthologues


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3756 SN Ps

5 Cross References

20 Data Sets

11 Homologues

2 Located Features

97 Rna Seq Results