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Gene : KIFAP3 Homo sapiens

Name  ? kinesin associated protein 3 Cytological Location  1q24.2
Brief Description  kinesin associated protein 3
Description  The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
  • synonyms:
  • Smg GDS,
  • HGNC:17060,
  • NM_014970,
  • KAP-1,
  • Smg-GDS,
  • FLA3,
  • FLA3,
  • dJ190I16.1,
  • uc001ggv.4,
  • KIFAP3,
  • OTTHUMG00000035947,
  • SMAP,
  • kinesin-associated protein 3,
  • SMAP,
  • KAP-3,
  • KAP3,
  • KAP3,
  • KAP-1,
  • U59919
  • identifiers:
  • 22920,
  • ENSG00000075945,
  • KIFAP3

Genome feature

Region: gene ? Length: 163878  
Location: 1:169921326-170085203 reverse strand Cyto location: 1q24.2

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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3753 SN Ps

5 Cross References

16 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results