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Gene : UBE2K Homo sapiens

Name  ? ubiquitin conjugating enzyme E2 K Cytological Location  4p14
Brief Description  ubiquitin conjugating enzyme E2 K
Description  The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • ubiquitin-conjugating enzyme E2K,
  • E2-25K,
  • ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast),
  • HYPG,
  • HIP2,
  • HYPG,
  • UBE2K,
  • LIG,
  • HGNC:4914,
  • OTTHUMG00000160543,
  • UBC1,
  • U58522,
  • huntingtin interacting protein 2,
  • uc003guu.5,
  • UBC1,
  • NM_005339,
  • HIP2
  • identifiers:
  • 3093,
  • ENSG00000078140,
  • UBE2K

Genome feature

Region: gene ? Length: 84657  
Location: 4:39698136-39782792 Cyto location: 4p14


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Function

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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

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Other

3756 SN Ps

5 Cross References

17 Data Sets

36 Homologues

0 Located Features

97 Rna Seq Results