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Gene : MAP3K4 Homo sapiens

Name  ? mitogen-activated protein kinase kinase kinase 4 Cytological Location  6q26
Brief Description  mitogen-activated protein kinase kinase kinase 4
Description  The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]
  • synonyms:
  • NM_001291958,
  • MEKK 4,
  • KIAA0213,
  • MAPKKK4,
  • MTK1,
  • AF002715,
  • HGNC:6856,
  • MAPKKK4,
  • MAP3K4,
  • MEKK4,
  • uc003qtn.4,
  • OTTHUMG00000015968,
  • PRO0412,
  • MEKK4,
  • MTK1
  • identifiers:
  • 4216,
  • ENSG00000085511,
  • MAP3K4

Genome feature

Region: gene ? Length: 125865  
Location: 6:160991521-161117385 Cyto location: 6q26

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577 SN Ps

5 Cross References

17 Data Sets

51 Homologues

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97 Rna Seq Results