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Gene : VRK1 Homo sapiens

Name  ? VRK serine/threonine kinase 1 Cytological Location  14q32.2
Brief Description  VRK serine/threonine kinase 1
Description  This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]
  • synonyms:
  • vaccinia related kinase 1,
  • PCH1A,
  • HGNC:12718,
  • NM_003384,
  • uc001yft.4,
  • OTTHUMG00000171459,
  • AB000449,
  • VRK1,
  • PCH1
  • identifiers:
  • 7443,
  • ENSG00000100749,
  • VRK1

Genome feature

Region: gene ? Length: 84233  
Location: 14:96797382-96881614 Cyto location: 14q32.2


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Proteins

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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Homology

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Expression

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Other

3756 SN Ps

5 Cross References

19 Data Sets

19 Homologues

0 Located Features

97 Rna Seq Results