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Gene : PYCARD Homo sapiens

Name  ? PYD and CARD domain containing Cytological Location  16p11.2
Brief Description  PYD and CARD domain containing
Description  This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • TMS-1,
  • apoptosis-associated speck-like,
  • ASC,
  • PYCARD,
  • ASC,
  • CARD5,
  • uc010cak.4,
  • TMS,
  • AB023416,
  • OTTHUMG00000176753,
  • HGNC:16608,
  • TMS1,
  • TMS-1,
  • NM_013258,
  • CARD5,
  • apoptosis-associated speck-like protein containing a CARD
  • identifiers:
  • 29108,
  • ENSG00000103490,
  • PYCARD

Genome feature

Region: gene ? Length: 1291  
Location: 16:31201486-31202776 reverse strand Cyto location: 16p11.2


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Disease

0 Diseases

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Expression

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709 SN Ps

5 Cross References

17 Data Sets

15 Homologues

0 Located Features

97 Rna Seq Results