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Gene : PLAT Homo sapiens

Name  ? plasminogen activator, tissue type Cytological Location  8p11.21
Brief Description  plasminogen activator, tissue type
Description  This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
  • synonyms:
  • PLAT,
  • uc003xos.3,
  • OTTHUMG00000164072,
  • HGNC:9051,
  • TPA,
  • plasminogen activator, tissue,
  • NM_000930,
  • T-PA
  • identifiers:
  • 5327,
  • ENSG00000104368,
  • PLAT

Genome feature

Region: gene ? Length: 32848  
Location: 8:42174718-42207565 reverse strand Cyto location: 8p11.21


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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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Other

3756 SN Ps

5 Cross References

20 Data Sets

11 Homologues

0 Located Features

97 Rna Seq Results