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Gene : SOD3 Homo sapiens

Name  ? superoxide dismutase 3 Cytological Location  4p15.2
Brief Description  superoxide dismutase 3
Description  This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]
  • synonyms:
  • NM_003102,
  • EC-SOD,
  • superoxide dismutase 3, extracellular,
  • SOD3,
  • OTTHUMG00000128565,
  • EC-SOD,
  • uc003gqz.4,
  • HGNC:11181
  • identifiers:
  • 6649,
  • ENSG00000109610,
  • SOD3

Genome feature

Region: gene ? Length: 5368  
Location: 4:24795478-24800845 Cyto location: 4p15.2


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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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Other

394 SN Ps

5 Cross References

17 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results