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Gene : RAPGEF2 Homo sapiens

Name  ? Rap guanine nucleotide exchange factor 2 Cytological Location  4q32.1
Brief Description  Rap guanine nucleotide exchange factor 2
description  Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
  • synonyms:
  • KIAA0313,
  • RA-GEF,
  • DKFZP586O1422,
  • RAPGEF2,
  • RAGEF,
  • RA-GEF,
  • Rap GEP,
  • CNrasGEF,
  • PDZ-GEF1,
  • RA-GEF-1,
  • AB002311,
  • PDZ-GEF1,
  • PDZ domain containing guanine nucleotide exchange factor (GEF) 1,
  • NM_014247,
  • nRap GEP,
  • HGNC:16854,
  • Rap guanine nucleotide exchange factor (GEF) 2,
  • OTTHUMG00000161451,
  • PDZGEF1,
  • uc003iqg.5,
  • Rap-GEP,
  • identifiers:
  • 9693,
  • ENSG00000109756,

Genome feature

Region: gene ? Length: 256123  
Location: 4:159104051-159360173 Cyto location: 4q32.1

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1 Diseases

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806 SN Ps

5 Cross References

17 Data Sets

30 Homologues

0 Located Features

97 Rna Seq Results