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Gene : NR3C1 Homo sapiens

Name  ? nuclear receptor subfamily 3 group C member 1 Cytological Location  5q31.3
Brief Description  nuclear receptor subfamily 3 group C member 1
Description  This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
  • synonyms:
  • uc003lnd.3,
  • X03225,
  • NR3C1,
  • nuclear receptor subfamily 3, group C, member 1,
  • NM_000176,
  • OTTHUMG00000129677,
  • GCRST,
  • GR,
  • nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor),
  • GRL,
  • GRL,
  • GCR,
  • HGNC:7978,
  • GCCR,
  • glucocorticoid receptor,
  • GR
  • identifiers:
  • 2908,
  • ENSG00000113580,
  • NR3C1

Genome feature

Region: gene ? Length: 157582  
Location: 5:143277931-143435512 reverse strand Cyto location: 5q31.3

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1 Diseases

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384 SN Ps

5 Cross References

20 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results