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Gene : TIA1 Homo sapiens

Name  ? TIA1 cytotoxic granule associated RNA binding protein Cytological Location  2p13.3
Brief Description  TIA1 cytotoxic granule associated RNA binding protein
Description  The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
  • synonyms:
  • TIA-1,
  • HGNC:11802,
  • nucleolysin TIA-1 isoform p40,
  • NM_022037,
  • TIA1,
  • T-cell-restricted intracellular antigen-1,
  • TIA1 cytotoxic granule-associated RNA-binding protein,
  • uc002sgk.5,
  • TIA-1,
  • WDM,
  • OTTHUMG00000129644
  • identifiers:
  • 7072,
  • ENSG00000116001,
  • TIA1

Genome feature

Region: gene ? Length: 39350  
Location: 2:70209444-70248793 reverse strand Cyto location: 2p13.3


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Disease

1 Diseases

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376 SN Ps

5 Cross References

17 Data Sets

14 Homologues

0 Located Features

97 Rna Seq Results