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Gene : TNFSF10 Homo sapiens

Name  ? TNF superfamily member 10 Cytological Location  3q26.31
Brief Description  TNF superfamily member 10
Description  The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • synonyms:
  • uc003fid.3,
  • OTTHUMG00000156917,
  • HGNC:11925,
  • Apo-2L,
  • TNFSF10,
  • TRAIL,
  • TL2,
  • TRAIL,
  • CD253,
  • APO2L,
  • TL2,
  • TNLG6A,
  • NM_001190942,
  • U37518,
  • CD253,
  • Apo-2L,
  • tumor necrosis factor (ligand) superfamily, member 10
  • identifiers:
  • 8743,
  • ENSG00000121858,
  • TNFSF10

Genome feature

Region: gene ? Length: 17923  
Location: 3:172505508-172523430 reverse strand Cyto location: 3q26.31


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194 SN Ps

5 Cross References

18 Data Sets

5 Homologues

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97 Rna Seq Results