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Gene : PLCG1 Homo sapiens

Name  ? phospholipase C gamma 1 Cytological Location  20q12
Brief Description  phospholipase C gamma 1
description  The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • phospholipase C, gamma 1,
  • PLC148,
  • PLC1,
  • NCKAP3,
  • PLCgamma1,
  • M34667,
  • OTTHUMG00000033082,
  • PLC-II,
  • NCKAP3,
  • uc002xjo.2,
  • PLCG1,
  • phospholipase C, gamma 1 (formerly subtype 148),
  • PLC148,
  • PLC1,
  • HGNC:9065,
  • PLC-II,
  • NM_182811,
  • PLCgamma1
  • identifiers:
  • 5335,
  • ENSG00000124181,
  • PLCG1

Genome feature

Region: gene ? Length: 40108  
Location: 20:41137519-41177626 Cyto location: 20q12

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92 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



92 Pathways

142 SN Ps

5 Cross References

17 Data Sets

20 Homologues

0 Located Features

97 Rna Seq Results